Semaglutide-Associated Ischemic Colitis in a Patient Without Traditional Risk Factors: A Case Report

This report describes the case of a 43-year-old female patient presenting with left lower quadrant pain and bloody diarrhea, initially managed as infectious colitis. Despite treatment, symptoms persisted, leading to repeat imaging showing mild pancolitis with colon mucosal hyperenhancement and wall thickening. Admission for intravenous hydration and subsequent colonoscopy revealed findings consistent with ischemic colitis. Semaglutide (Ozempic), which the patient had been taking, was discontinued, and symptoms resolved post discharge without semaglutide use for several months. This suggests a potential association between semaglutide and ischemic colitis in a patient without known risk factors. This case underscores the importance of considering medication-induced colitis in patients presenting with persistent gastrointestinal symptoms, particularly in the absence of typical risk factors.