HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients
Our findings suggest that HSP90 and LMNA mediated the formation and nuclear localization of the HGEO complex, thereby enhancing the malignant traits and resistance mechanisms in gastric cancer. Targeting this pathway may offer a novel therapeutic strategy to improve treatment outcomes.
Authors
- Gaigai Shen
- Shiya Liu (ORCID: https://orcid.org/0000-0002-0245-9961)
- Yuliang Ran (ORCID: https://orcid.org/0000-0003-2555-1311)
- Guanghui Wang (ORCID: https://orcid.org/0000-0002-3730-5575)
- Zihao Chen (ORCID: https://orcid.org/0000-0003-0402-5259)
- Long Yu
- Yuanting Cao
- Lixin Sun (ORCID: https://orcid.org/0000-0002-8754-3176)
Institutions
- Qinghai University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1186/s12967-025-06196-w
- Citations
- 7
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Molecular Oncology
- National Key Research and Development Program of China