IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury
The IL-6/GATA2/SERPINE1 pathway mediates cellular senescence after acute kidney injury, and inhibiting IL-6 can alleviate AKI-induced cellular senescence, providing an important basis for exploring new therapeutic strategies.
Authors
- Feng Jiang (ORCID: https://orcid.org/0000-0002-9293-7479)
- Yinghui Guan (ORCID: https://orcid.org/0000-0003-1801-8332)
- L. Gong (ORCID: https://orcid.org/0009-0005-0778-3014)
- Songtao Shou (ORCID: https://orcid.org/0000-0002-9959-3963)
- Qi Lv (ORCID: https://orcid.org/0000-0001-9076-7042)
- Mengya Geng (ORCID: https://orcid.org/0000-0002-8822-963X)
- Heng Jin (ORCID: https://orcid.org/0000-0001-9264-1187)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-0035-543X)
- Xiaoxi Lin (ORCID: https://orcid.org/0009-0004-2500-2018)
- Congcong Yao (ORCID: https://orcid.org/0009-0005-4911-7730)
- Hongshuang Su (ORCID: https://orcid.org/0009-0002-0135-9114)
- Ayinuer Paredong
Institutions
- Tianjin University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-02-11
- DOI
- https://doi.org/10.3389/fmolb.2025.1538526
- Citations
- 10
- Primary Topic
- Muscle and Compartmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 20.06