Causal links between obesity, lipids, adipokines, and cognition: a bidirectional Mendelian-randomization analysis
Our MR reveals that high BMI, BFP, WHR and AgRP have negative causal direct effects with cognitive ability, while high HDL and ADPN have positive causal direct effects with cognitive ability. For the reverse causal direction, our consistent findings that worse cognitive function such as SRT and FIS may influence serum HDL level and BMI.
Authors
- Shiyi Qi
- Meng Gong (ORCID: https://orcid.org/0000-0002-1203-5820)
- Wang Yong-shen
- Song Jin (ORCID: https://orcid.org/0000-0002-3779-9464)
- Hong Guo (ORCID: https://orcid.org/0000-0001-5277-7637)
- Zhixiang Liu (ORCID: https://orcid.org/0000-0002-1135-1215)
- Haichao Liu (ORCID: https://orcid.org/0000-0003-1644-9884)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Fujian University of Traditional Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3389/fendo.2025.1439341
- Citations
- 7
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 12.72
Funders
- Sichuan Provincial Administration of Traditional Chinese Medicine