SMYD4 promotes MYH9 ubiquitination through lysine monomethylation modification to inhibit breast cancer progression
These findings reveal the emerging character of SMYD4 in Wnt/β‑catenin signaling and bring new sights of gene interaction. The discovery of this SMYD4/MYH9/CTNNB1/WNT/β-Catenin signalling pathway axis suggests that SMYD4 is a potential therapeutic target for breast cancer.
Authors
- Rui Sun (ORCID: https://orcid.org/0000-0002-5616-6849)
- Xue-Jie Zhou
- Xin Wang (ORCID: https://orcid.org/0000-0002-5122-2418)
- Xiaofeng Liu (ORCID: https://orcid.org/0000-0001-5596-7102)
- Yue Yu (ORCID: https://orcid.org/0000-0003-2053-9866)
- Bowen Liu (ORCID: https://orcid.org/0000-0001-8837-7870)
- Zhaohui Chen (ORCID: https://orcid.org/0000-0003-0688-9798)
- Junming Cao (ORCID: https://orcid.org/0009-0004-7581-2959)
- Junping Yang (ORCID: https://orcid.org/0009-0003-6360-8056)
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1186/s13058-025-01973-3
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China