Ginsenoside Rg2, a principal effective ingredient of Panax ginseng, attenuates DSS-induced ulcerative colitis through NF-κB/NLRP3 pathway
G-Rg2 effectively reduced colon inflammation in DSS-induced UC mice and diminishes inflammatory responses under LPS/Nig conditions by regulating NF-κB/NLRP3 pathway, thereby inhibiting NLRP3 inflammasome activation, which may serve as a potent therapeutic agent for UC.
Authors
- Long You (ORCID: https://orcid.org/0000-0001-6978-0066)
- Weicheng Hu (ORCID: https://orcid.org/0000-0002-6730-811X)
- Guigui Yang
- Rui Guo (ORCID: https://orcid.org/0000-0002-8234-9817)
- Zhiqiang Niu
- Ziliang He
- Ting Shen
- Ji Zhang (ORCID: https://orcid.org/0000-0002-8514-5692)
- Yanan Liu (ORCID: https://orcid.org/0000-0002-0091-7068)
- Jing Xie (ORCID: https://orcid.org/0009-0000-0537-8617)
- Yan Qi (ORCID: https://orcid.org/0000-0003-4316-8922)
- Honggang Wang (ORCID: https://orcid.org/0000-0003-4761-0407)
Institutions
- Huaian First People’s Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Huaiyin Normal University (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1016/j.jgr.2025.02.001
- Citations
- 11
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- National Natural Science Foundation of China
- Natural Science Research of Jiangsu Higher Education Institutions of China