Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells
AP4-2 and AP17-4 showed strong affinity and specificity for their target VLPs and represent promising candidates for HuNoV capture and detection. This is the first study to demonstrate that aptamers can effectively inhibit HuNoV VLPs from binding to or entering cells, thus providing a new concept for the treatment of HuNoVs.
Authors
- Shouhong Xu (ORCID: https://orcid.org/0000-0002-6019-0585)
- Mingyue Sun (ORCID: https://orcid.org/0000-0002-4171-4195)
- Jing Liu (ORCID: https://orcid.org/0000-0002-4036-789X)
- Yitong Xue
- Jingjing Li (ORCID: https://orcid.org/0000-0003-3241-2248)
- Youhua Xie
- Xia Cai (ORCID: https://orcid.org/0000-0003-2971-6689)
- Xiaolian Wang (ORCID: https://orcid.org/0009-0007-1158-0871)
- Junqi Zhang (ORCID: https://orcid.org/0009-0001-4733-023X)
- Chao Cheng (ORCID: https://orcid.org/0000-0002-9380-3296)
Institutions
- Shanghai Medical College of Fudan University (CN)
- East China University of Science and Technology (CN)
- Fudan University (CN)
- Hexi University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijn.s495399
- Citations
- 2
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project
- National Key Research and Development Program of China