Altered Functional Connectivity and Amyloid Deposition in Posttraumatic Stress Disorder–Associated Cognitive Impairment
The findings suggest that elevated amyloid and altered connectivity patterns are associated with cognitive impairment in PTSD, particularly in the temporal and parietal regions. In contrast, PTSD without cognitive decline was associated with functional connectivity changes in salience and sensorimotor networks but no increased amyloid deposition. This study underscores the importance of neuroimaging biomarkers in understanding PTSD-related cognitive decline and suggests avenues for further investigation into the mechanistic pathways involved.
Authors
- Max Wintermark (ORCID: https://orcid.org/0000-0002-6726-3951)
- Haris I. Sair (ORCID: https://orcid.org/0000-0002-5077-0471)
- Daniel A. Stevens (ORCID: https://orcid.org/0000-0002-7076-794X)
- Vivek Srikar Yedavalli (ORCID: https://orcid.org/0000-0002-2450-4014)
- Richard Dagher (ORCID: https://orcid.org/0009-0001-7666-2989)
- Licia Luna (ORCID: https://orcid.org/0000-0003-3539-4831)
- Parisa Arjmand
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- University Hospitals of Cleveland (US)
- Johns Hopkins Medicine (US)
- Behavioral Pharma (United States) (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- American Journal of Neuroradiology
- Published
- 2025-02-10
- DOI
- https://doi.org/10.3174/ajnr.a8694
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00