Diagnosis and Treatment of Patients with Autoimmune Hepatitis (Experts’ Agreement)
Background. In the last decade, the understanding of the pathogenesis of autoimmune hepatitis (AIH) has significantly deepened, based on the results of new clinical studies some diagnostic issues have been revised and immunosuppressive therapy regimens have been optimized. Materials and methods. The latest Russian clinical guidelines for the diagnosis and treatment of AIH were presented in 2013; and in 2017, the first Russian agreement on the diagnosis and treatment of AIH was held. Updating approaches to the management of patients with AIH necessitated next systematization for use in clinical practice. In February 2024, the final session was held to discuss the provisions of the second agreement on the diagnosis and treatment of AIH. Results. This publication presents the main discussion points of the agreement regarding methods and algorithms for detecting autoantibodies, the role of liver biopsy, revised morphological criteria for AIH, optimized immunosuppressive therapy regimens, updated criteria for assessing the response to therapy. Conclusions. The agreement was the result of the work of a group of experts on the diagnosis and treatment of AIH and represents the basis for the creation of updated federal clinical guidelines.
Authors
- С. В. Лапин
- Sergey Batskikh (ORCID: https://orcid.org/0000-0002-5917-203X)
- С Г Хомерики (ORCID: https://orcid.org/0000-0003-4308-8009)
- E. V. Vinnitskaya (ORCID: https://orcid.org/0000-0002-0344-8375)
- A. I. Dolgushina (ORCID: https://orcid.org/0000-0003-2569-1699)
- А. О. Буеверов (ORCID: https://orcid.org/0000-0002-5041-3466)
- N. V. Korochanskaya (ORCID: https://orcid.org/0000-0002-5538-9418)
- М. С. Журавлева (ORCID: https://orcid.org/0000-0003-4838-5707)
- T. Yu. Кhaimenova (ORCID: https://orcid.org/0000-0002-4599-4040)
- А. А. Новиков (ORCID: https://orcid.org/0000-0002-2738-2956)
- М. К. Прашнова (ORCID: https://orcid.org/0000-0002-5402-8266)
- Игорь Геннадьевич Бакулин (ORCID: https://orcid.org/0000-0002-6151-2021)
- Kliaritskaia Il (ORCID: https://orcid.org/0000-0001-9840-7885)
- Yu.G. Sandler (ORCID: https://orcid.org/0000-0003-4291-812X)
- Д. И. Абдулганиева (ORCID: https://orcid.org/0000-0001-7069-2725)
- М. V. Maevskaya (ORCID: https://orcid.org/0000-0001-8913-140X)
- V. Е. Syutkin (ORCID: https://orcid.org/0000-0001-8391-5211)
- Nikolay Karnaukhov (ORCID: https://orcid.org/0000-0003-0889-2720)
- Р. Г. Сайфутдинов (ORCID: https://orcid.org/0000-0003-2839-100X)
- L. Yu. Ilchenko (ORCID: https://orcid.org/0000-0001-6029-1864)
- К. В. Ивашкин (ORCID: https://orcid.org/0000-0002-5699-541X)
- Н. В. Марченко (ORCID: https://orcid.org/0000-0002-6738-6417)
- K. L. Raikhelson (ORCID: https://orcid.org/0000-0002-8821-6142)
- Т. П. Некрасова (ORCID: https://orcid.org/0000-0001-6376-9392)
- М. А. Ливзан (ORCID: https://orcid.org/0000-0002-6581-7017)
- Е Н Александрова (ORCID: https://orcid.org/0000-0003-4074-5907)
- Dzhamal Abdurakhmanov (ORCID: https://orcid.org/0000-0002-3160-2771)
- Ekaterina V. Skazyvaeva (ORCID: https://orcid.org/0000-0002-8563-6870)
- В. Е. Карев (ORCID: https://orcid.org/0000-0002-7972-1286)
- И. Г. Никитин (ORCID: https://orcid.org/0000-0003-1699-0881)
- О. А. Герасимова (ORCID: https://orcid.org/0000-0003-2690-5062)
- S. L. Vorobyev
Institutions
- Kuban State Medical University (RU)
- St Petersburg University (RU)
- Morpho (United States) (US)
- Sechenov University (RU)
- Kazan State Medical University (RU)
- Omsk State Medical University (RU)
- First Pavlov State Medical University of St. Petersburg (RU)
- Chelyabinsk State Medical Academy (RU)
- Pirogov Russian National Research Medical University (RU)
- Moscow Clinical Scientific Center (RU)
- Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency (RU)
- Russian Medical Academy of Continuous Professional Education (RU)
- Kazan State Medical Academy (RU)
- Russian Scientific Center of Radiology and Surgical Technologies (RU)
- North-Western State Medical University named after I.I. Mechnikov (RU)
- V.I. Vernadsky Crimean Federal University (UA)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Russian Journal of Gastroenterology Hepatology Coloproctology
- Published
- 2024-12-30
- DOI
- https://doi.org/10.22416/1382-4376-2024-34-6-100-119
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00