GrpEL1 overexpression mitigates hippocampal neuron damage via mitochondrial unfolded protein response after experimental status epilepticus
GrpEL1 plays a crucial role in maintaining mitochondrial proteostasis and mitigating hippocampal neuronal injury following SE by regulating UPRmt. These findings suggest that GrpEL1 may represent a promising target for therapeutic intervention to protect against seizure-induced neurodegeneration.
Authors
- Lei Bai (ORCID: https://orcid.org/0000-0001-8968-3386)
- Xinyu Tao (ORCID: https://orcid.org/0000-0003-0023-8759)
- Haitao Shen (ORCID: https://orcid.org/0000-0001-9296-3725)
- Zongqi Wang (ORCID: https://orcid.org/0000-0003-4559-3420)
- Minjia Xie
- Xi Liu (ORCID: https://orcid.org/0000-0003-3142-7843)
- Li Di (ORCID: https://orcid.org/0000-0001-6117-9022)
- Feng Gu
- Long‐Yuan Li (ORCID: https://orcid.org/0000-0001-7472-8318)
- Wei Gao (ORCID: https://orcid.org/0000-0003-2017-6153)
- Bingyi Song
- Xin Wu
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1016/j.nbd.2025.106838
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.42