Influence of estradiol deficiency on the mineralocorticoid receptor response in postmenopausal women: a cross-sectional study
Our results suggest enhanced MR sensitivity not only in PostM-HT, as evidenced by lower PRA and elevated FEK, but also in PostM-NT, who exhibited greater FEK and NGAL levels, surrogate markers of MR activation. These results support a novel role of MR activation and cardiovascular risk in PostM women.
Authors
- Jorge A Pérez (ORCID: https://orcid.org/0000-0003-4745-6219)
- Alejandra Martínez (ORCID: https://orcid.org/0000-0002-8484-8126)
- Carlos Fardella (ORCID: https://orcid.org/0000-0002-5500-4434)
- Patricio Lepe Carrión
- Alejandra Tapia-Castillo (ORCID: https://orcid.org/0000-0002-6081-1468)
- Marlín Solórzano (ORCID: https://orcid.org/0000-0001-5478-7337)
- Cristián A. Carvajal (ORCID: https://orcid.org/0000-0002-0668-412X)
- Maria P Hernandez
Institutions
- Pontificia Universidad Católica de Chile (CL)
- Millennium Institute on Immunology and Immunotherapy (CL)
Publication Details
- Journal
- Climacteric
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1080/13697137.2025.2455181
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00