The impact of lymph node dissection on stage I ovarian endometrioid carcinoma: A US-China Comparative Analysis
This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify the optimal LND range for improved survival. By analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database conducted in USA and NUWA database in China, we found that patients who underwent LND in the SEER cohort exhibited significantly improved long-term survival rates compared to those who did not undergo LND, while the difference was not statistically significant in the NUWA cohort. Cox regression and restricted cubic spline analyses indicated an inverted U-shaped association between the number of LNDs and hazard ratios, identifying 29-34 lymph nodes as the optimal range. This finding suggests that performing LND within this specified range may enhance survival outcomes for patients with stage I OEC.
Authors
- Danbo Wang (ORCID: https://orcid.org/0000-0002-8925-364X)
- Fei Lin (ORCID: https://orcid.org/0000-0003-3489-1959)
- Liangsheng Fan (ORCID: https://orcid.org/0000-0003-0043-3108)
- Shuzhong Yao
- Qinglei Gao (ORCID: https://orcid.org/0000-0002-9448-3423)
- Jiangtao Fan (ORCID: https://orcid.org/0000-0003-1308-4533)
- Jing Shi (ORCID: https://orcid.org/0000-0003-0043-8507)
- Yi Huang (ORCID: https://orcid.org/0000-0002-8379-9684)
- Meige Sun (ORCID: https://orcid.org/0000-0003-3492-0799)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Wei Wang (ORCID: https://orcid.org/0000-0002-1614-0759)
- Youguo Chen (ORCID: https://orcid.org/0000-0001-8026-664X)
- Jialing Chen (ORCID: https://orcid.org/0000-0001-5186-3488)
- Xiang‐Guang Wu (ORCID: https://orcid.org/0000-0001-8276-4810)
- Yunyi Liang
Institutions
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Soochow University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Tongji Hospital (CN)
- Hubei Cancer Hospital (CN)
- Liaoning Cancer Hospital & Institute (CN)
- Huazhong University of Science and Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- iScience
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1016/j.isci.2025.111986
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca