Neurobehavioral deficits of AlCl3 attenuated by administration of Turmeric supplementation in rats

Turmeric is a very commonly used medicinal plant.Its main phytochemical component is curcumin.It is known to possess a neuroprotective, anti-inflammatory and antihypertensive properties.Dementia has a crucial impact on physical and emotional well-being of patients.It is a clinical syndrome indicated by a gradual decrease in cognitive function which obstruct one's ability to live autonomously.It is widely used in foods and well known about its analgesic effects.Purpose of current study is to know about its effect on brain functions and possible effects on antioxidant mechanism which will be helpful to rule out different possible neuronal disorders.Eighteen rats were taken and divided into three groups control and two tests.Control was given saline while tests were given intraperitoneal (i.p) AlCl3 for 21 days at a dose of 50mg/kg/ml and the second test group was co-treated with orally turmeric 90mg/kg.Memory functions were evaluated by using the Morris water maze test while biochemical test perform using blood samples and brain sample used for antioxidant effects.In Morris water maze test AlCl3administered group shows increase in latency time showing memory impairment that attenuated by turmeric supplement with wound formation in skin.The co-treated group 2 showed improved memory functions and biochemical effects while recovery of wounds also seen.Present study showed that Turmeric can attenuate dementia caused by AlCl3 and healing different wounds.AlCl3 also induced hyperglycemia effect that is attenuated by turmeric administration.Present study suggests that turmeric would be helpful against AlCl3 induced dementia and its prevention.