Benchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis
PCCTA compares favorably with ICA for lumen assessment and anatomic disease severity classification in patients presenting with acute coronary syndrome or patients referred for ICA. UHR-PCCTA luminal evaluation is superior to SR-PCCTA, especially in patients with heavy coronary calcification. UHR-PCCTA has excellent diagnostic performance in identifying coronary arteries with ≥50% luminal stenosis on 3D QCA, outperforming standard-resolution imaging.
Authors
- David Holdsworth (ORCID: https://orcid.org/0000-0003-2465-1521)
- Keith M. Channon (ORCID: https://orcid.org/0000-0002-1043-4342)
- Nikant Sabharwal (ORCID: https://orcid.org/0000-0002-1989-947X)
- Andrew Lucking
- Sheena Thomas (ORCID: https://orcid.org/0000-0002-2097-465X)
- Leonardo Portolan
- Jason Walsh (ORCID: https://orcid.org/0000-0001-5538-4206)
- Giovanni Luigi De Maria (ORCID: https://orcid.org/0000-0003-3572-1855)
- Jeremy P. Langrish
- Rafail A. Kotronias (ORCID: https://orcid.org/0000-0001-8132-6130)
- Stefan Neubauer (ORCID: https://orcid.org/0000-0001-9017-5645)
- Adrian Banning (ORCID: https://orcid.org/0000-0002-2842-7861)
- Caroline S. Taylor (ORCID: https://orcid.org/0000-0002-9042-9913)
- Kenneth Chan (ORCID: https://orcid.org/0000-0002-5571-7549)
- Thomas Halborg
- Robyn Farrall
- Cheng Xie (ORCID: https://orcid.org/0000-0002-8075-9396)
- Thomas J. Cahill (ORCID: https://orcid.org/0000-0003-4318-5618)
- Charalambos Antoniades
- Jonathan Denton
Institutions
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
Publication Details
- Journal
- JACC. Cardiovascular imaging
- Published
- 2025-02-10
- DOI
- https://doi.org/10.1016/j.jcmg.2024.11.005
- Citations
- 18
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 24.48
Funders
- Amgen
- Amarin Corporation
- National Institute for Health and Care Research
- British Heart Foundation
- University of Oxford
- Alexander S. Onassis Public Benefit Foundation
- Silence Therapeutics
- NIHR Oxford Biomedical Research Centre