<i>PCSK9</i> and <i>APOA4</i>: The Dynamic Duo in TMAO-induced Cholesterol Metabolism and Cholelithiasis
TMAO upregulated hepatic <i>PCSK9</i> expression and reduced <i>APOA4</i> expression, initiating a feedback loop that dysregulated cholesterol metabolism and promoted lithogenesis.
Authors
- Dongbo Xue (ORCID: https://orcid.org/0000-0001-9012-4805)
- Jingjing Yu (ORCID: https://orcid.org/0000-0001-8938-4298)
- Xianzhi Meng (ORCID: https://orcid.org/0000-0003-3409-4693)
- Chao Shi (ORCID: https://orcid.org/0000-0003-3950-4268)
- Da-Yong Lu (ORCID: https://orcid.org/0000-0002-9026-8558)
- Huiru Ding (ORCID: https://orcid.org/0000-0003-1798-5806)
- Guoxin Shi (ORCID: https://orcid.org/0009-0009-1797-952X)
- Zhang Meng
- Haijun Sun
Institutions
- Harbin Medical University (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-02-11
- DOI
- https://doi.org/10.14218/jcth.2024.00403
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00