Efficacy, Immunogenicity, and Safety of the Bivalent Respiratory Syncytial Virus (RSV) Prefusion F Vaccine in Older Adults Over 2 RSV Seasons
High RSV neutralizing titers were observed 1 month after RSVpreF vaccination in persons aged ≥60 years, with similarly robust responses across subgroups. These immune responses corresponded with high RSVpreF VE against RSV-associated LRTI. RSVpreF had a favorable safety profile over 2 seasons. Clinical Trials Registration. NCT05035212; EudraCT, 2021-003693-31.
Authors
- Maria Maddalena Lino
- Agnieszka Zareba (ORCID: https://orcid.org/0000-0003-4118-6879)
- Elena Kalinina (ORCID: https://orcid.org/0000-0003-0180-090X)
- Yasushi Fukushima (ORCID: https://orcid.org/0000-0002-6148-215X)
- Mika Rämet (ORCID: https://orcid.org/0000-0002-5776-164X)
- Kena A. Swanson (ORCID: https://orcid.org/0000-0002-3389-8414)
- Tarek Mikati
- Kumar Ilangovan
- Iona Munjal
- Alejandra Gurtman (ORCID: https://orcid.org/0000-0003-3469-1201)
- José F. Cardona
- Edward E. Walsh (ORCID: https://orcid.org/0000-0002-8792-8877)
- Conrado J. Llapur
- Qin Jiang (ORCID: https://orcid.org/0000-0001-8233-8993)
- Nazreen Hussen
- Daniel Eiras
- Gonzalo Pérez Marc
- Michael A. Patton
- John Woodside
Institutions
- Universidad Mayor de San Andrés (BO)
- Florida Department of Health (US)
- Tampere University of Applied Sciences (FI)
- Tampere University (FI)
- Pfizer (United States) (US)
- Pfizer (United Kingdom) (GB)
- University of Rochester Medical Center (US)
- Finnish Diabetes Association (FI)
- Hospital Militar Central (CO)
- Lakeview Hospital (US)
- Fukuda Denshi (Japan) (JP)
- Tampere University (FI)
- Netcare Unitas Hospital (ZA)
- Pfizer (Italy) (IT)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1093/cid/ciaf061
- Citations
- 34
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 46.04