Sex and outcomes of patients with microsatellite instability-high and <i>BRAF</i> V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors
Overall, our findings suggest a complex interplay between sex and <i>BRAF</i> mutational status that may modulate the activity of ICIs in patients with MSI-H mCRC and pave the way to novel tailored strategies.
Authors
- Michael J. Overman (ORCID: https://orcid.org/0000-0001-5377-135X)
- Nicholas J. Hawkins (ORCID: https://orcid.org/0000-0002-2204-3189)
- Priya Jayachandran (ORCID: https://orcid.org/0009-0002-2480-4057)
- Rossana Intini (ORCID: https://orcid.org/0000-0001-8428-0721)
- Claire Gallois (ORCID: https://orcid.org/0000-0003-2369-7341)
- Marco Vitellaro (ORCID: https://orcid.org/0000-0001-8134-5315)
- Filippo Ghelardi (ORCID: https://orcid.org/0009-0001-1820-4402)
- Jitendra Jonnagaddala (ORCID: https://orcid.org/0000-0002-9912-2344)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Joseph Jonathan Zhao (ORCID: https://orcid.org/0000-0002-2002-5390)
- Giacomo Mazzoli
- Lisa Salvatore (ORCID: https://orcid.org/0000-0003-3864-0719)
- Francesca Bergamo (ORCID: https://orcid.org/0000-0002-8795-4653)
- Javier Carmona (ORCID: https://orcid.org/0000-0003-1281-301X)
- Élena Elez (ORCID: https://orcid.org/0000-0002-4653-6324)
- Michael Hoffmeister (ORCID: https://orcid.org/0000-0002-8307-3197)
- Koen Zwart (ORCID: https://orcid.org/0000-0002-0369-4509)
- David Tougeron (ORCID: https://orcid.org/0000-0002-8065-9635)
- Romain Cohen (ORCID: https://orcid.org/0000-0001-9602-5162)
- Jeroen W. G. Derksen (ORCID: https://orcid.org/0000-0002-2973-5583)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Durgesh Wankhede (ORCID: https://orcid.org/0000-0003-2583-9032)
- Raghav Sundar (ORCID: https://orcid.org/0000-0001-9423-1368)
- Marta Ligero (ORCID: https://orcid.org/0000-0001-9824-7316)
- Miriam Koopman (ORCID: https://orcid.org/0000-0003-1550-1978)
- Marwan Fakih (ORCID: https://orcid.org/0000-0002-6554-5488)
- Jeanine M.L. Roodhart (ORCID: https://orcid.org/0000-0003-1398-8970)
- Vincenzo Nasca (ORCID: https://orcid.org/0000-0002-7897-402X)
- Javier Ros (ORCID: https://orcid.org/0000-0002-8137-5415)
- Robyn L. Ward (ORCID: https://orcid.org/0000-0002-6877-8906)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Filippo Pietrantonio (ORCID: https://orcid.org/0000-0002-8530-8420)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Pierre Laurent‐Puig (ORCID: https://orcid.org/0000-0001-8475-5459)
- Jakob Nikolas Kather
Institutions
- University of Southern California (US)
- The University of Sydney (AU)
- The University of Texas MD Anderson Cancer Center (US)
- Inserm (FR)
- German Cancer Research Center (DE)
- Utrecht University (NL)
- Université Paris Cité (FR)
- Heidelberg University (DE)
- Agostino Gemelli University Polyclinic (IT)
- University Medical Center Utrecht (NL)
- UNSW Sydney (AU)
- Yale University (US)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Saint-Antoine (FR)
- Fresenius (Germany) (DE)
- Istituto Oncologico Veneto (IT)
- City of Hope (US)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Vall d'Hebron Hospital Universitari (ES)
- National University Hospital (SG)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010598
- Citations
- 4
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Conquer Cancer Foundation
- Amgen
- Sanofi
- F. Hoffmann-La Roche
- Les Laboratories Pierre Fabre
- National University of Singapore
- Associazione Italiana per la Ricerca sul Cancro