A murine model of aortic regurgitation generated by trans‐apical wire destruction of the aortic valve
The trans-apex wire-induced destruction of the AoV establishes a novel and efficient murine model to develop AR, characterized by significant eccentric LV hypertrophy, heart failure, and pulmonary congestion.
Authors
- Jianping Bin
- Yulin Liao (ORCID: https://orcid.org/0000-0001-5961-390X)
- Wangjun Liao (ORCID: https://orcid.org/0000-0002-1364-8442)
- Cankun Zheng (ORCID: https://orcid.org/0000-0002-0815-646X)
- Mengjia Shen (ORCID: https://orcid.org/0000-0003-1748-3726)
- Zhihong Li (ORCID: https://orcid.org/0000-0002-1944-9671)
- Dan Han (ORCID: https://orcid.org/0000-0003-4871-4371)
- Xiaoxia Huang (ORCID: https://orcid.org/0000-0001-6566-0649)
- Qiancheng Wang (ORCID: https://orcid.org/0000-0002-4842-6540)
- Hairuo Lin (ORCID: https://orcid.org/0000-0003-0413-3807)
- Z. Cong
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1002/ame2.12558
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province