Magnesium, calcium and vitamin D levels in polycystic ovarian syndrome: a retrospective single center study

Aims: Polycystic ovary syndrome (PCOS); It is an endocrine-gynecological disorder that affects many women of reproductive age, with chronic anovulation and androgen elevation. Although many pathophysiological processes have been discovered in the development of PCOS; The exact etiology and pathophysiology have not been fully elucidated. Vitamin D is synthesized differently from other vitamins and vitamin D has a hormonal function in the body. Vitamin D is known to have a role in many diseases, as well as its effects on bone metabolism in the body. We aimed to examine the relationship between PCOS and serum vitamin D, calcium and magnesium levels. Methods: A total of 80 cases, including 40 patients diagnosed with PCOS according to the Rotterdam criteria and 40 cases in the normal population, were included in the study. The cases were examined retrospectively. Magnesium, calcium and vitamin D levels of all cases were compared. Additionally, the hemogram parameters, insulin, glucose, insulin resistance, HbA1c, high-density lipoprotein, low-density lipoprotein, triglyceride, total cholesterol, parathormone and phosphorus levels of the cases were compared. Results: There was no difference in magnesium, calcium, vitamin D values between cases with and without polycystic ovary syndrome, and no difference in hemogram parameters, HbA1c, glucose, insulin, parathormone and phosphorus levels between the same groups (p>0.05). When lipid levels were compared, total cholesterol and low-density lipoprotein levels were found to be significantly higher in those without PCOS (p = 0.042). The average age was found to be significantly lower in patients with PCOS (p<0.001). Conclusion: In our study, no significant difference was seen between the two groups in terms of magnesium, calcium and vitamin D levels. Prospective observational studies and randomized controlled studies are needed to more clearly explain the relationship between hormonal and metabolic irregularities and magnesium, calcium and vitamin D levels in PCOS.