Vulvar and vaginal graft versus host disease in a patient with chronic phase chronic myeloid leukemia after allogeneic stem cell transplantation

Graft versus Host Disease (GVHD) is one of the serious complications of allogeneic stem cell transplantation in the treatment of many hematological malignancies. Skin, liver, and eyes are frequently affected areas. In addition to frequently affected areas, genital region involvement can also be seen. Allogeneic stem cell transplantation is one of the definitive treatments for hematological malignancies seen in the young age group. And its use for therapeutic purposes in young patients is increasing daily. Vulvovaginal GVHD is a disease type that concerns female patients of reproductive age. In this case report, we wanted to report in the literature a case that underwent allogeneic stem cell transplantation after CML diagnosis and TKI resistance and then developed vulvovaginal GVHD. In vaginal disease involvement; in addition to many genitourinary complaints, many negativities in sexual life and deterioration in quality of life are experienced. The chronic GVHD patient we treated is currently continuing her treatment response follow-ups. Our aim in presenting this case to the literature is to emphasize that GVHD should be included in the differential diagnosis in female patients with hematological disease and vaginal involvement.