Clinical characteristics of semantic variant of primary progressive aphasia with TDP-43- and tau-related gene variants
The onset age in svPPA patients with tau pathology-related gene mutations is younger than in those with TDP-43 pathology-related gene mutations. MAPT variants, specifically P301L and IVS10 + 16C > T, as well as TARDBP I383V variant, may have higher mutation frequency in svPPA.
Authors
- Xiaoyang Lei (ORCID: https://orcid.org/0000-0002-3950-1545)
- Dian He (ORCID: https://orcid.org/0000-0003-0550-6249)
- Chao Tang (ORCID: https://orcid.org/0009-0001-7058-6591)
- Yayu Ma (ORCID: https://orcid.org/0009-0003-2658-6142)
- Li Ping Wang (ORCID: https://orcid.org/0000-0001-6893-3809)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/13872877241312932
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Major Science and Technology Projects of China