Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period
We identified that the <i>APOE4</i> genotype affected ΔHV in females. Our findings suggest that female <i>APOE4</i> carriers, unlike males, may be more susceptible than non-carriers to the underlying pathophysiological mechanisms of hippocampal atrophy in aMCI.
Authors
- Chang-Hyun Park (ORCID: https://orcid.org/0000-0001-5575-1467)
- Hwagyu Suh (ORCID: https://orcid.org/0000-0002-0360-6708)
- Byung Dae Lee (ORCID: https://orcid.org/0000-0003-4295-8463)
- Eunsoo Moon (ORCID: https://orcid.org/0000-0002-8863-3413)
- Hyunji Lee (ORCID: https://orcid.org/0000-0003-4375-2694)
- Kyoungjune Pak (ORCID: https://orcid.org/0000-0001-5051-1894)
- Kyungwon Kim (ORCID: https://orcid.org/0000-0001-8947-9078)
- Kyung Un Choi (ORCID: https://orcid.org/0000-0002-3848-1781)
- Chang‐Seok Kim (ORCID: https://orcid.org/0000-0002-2811-8137)
- Young Min Lee (ORCID: https://orcid.org/0000-0001-7483-7143)
- Hak Jin Kim (ORCID: https://orcid.org/0000-0003-2483-1469)
- Hwanwook Shim (ORCID: https://orcid.org/0000-0002-3824-2051)
Institutions
- Pusan National University Hospital (KR)
- Pusan National University (KR)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/13872877241313066
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Ministry of Health and Welfare
- Ministry of Science and ICT, South Korea