Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS‐CoV‐2 Infection: A Descriptive Study
This study aims to identify the risk factors associated with clinical outcomes and the proteomic changes in organs related to fatal SARS-CoV-2 infection within the super-elderly population. This retrospective analysis included all elderly individuals with COVID-19 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow-up period ended on March 30, 2023. During this time, epidemiological, demographic, laboratory, and outcome data were analyzed descriptively. Proteomic sequencing was performed on super-elderly patients who died from COVID-19 at different stages of the disease. A total of 352 elderly COVID-19 patients, with a mean age of 89.84 ± 8.54 years, were included in this study. During a median follow-up period of 98 days, 79 patients died. Deceased patients were older and more likely to have cardiovascular and cerebrovascular diseases, with a lower prevalence of lipid-lowering therapy. The number of deaths in the acute and post-acute phases were 34 and 45, respectively. Proteomics data suggest that the immune systems of patients who died in the acute phase underwent a more rapid and severe onslaught. Patients in the post-acute phase showed higher levels of viral genome replication and a more robust immune response. However, the over-activation of the immune system led to systemic organ dysfunction. Effective management of comorbidities may improve the prognosis of COVID-19 in super-elderly patients. The continuous replication of the SARS-CoV-2 virus and its subsequent impact on the immune system are critical determinants of survival time in this demographic.
Authors
- Shu Zhao
- Qing Chang (ORCID: https://orcid.org/0000-0001-5138-8760)
- Shuangtong Yan (ORCID: https://orcid.org/0000-0003-2344-4504)
- Qiangguo Ao (ORCID: https://orcid.org/0009-0002-7000-0789)
- Keyu Wang (ORCID: https://orcid.org/0000-0002-1973-9927)
- Ping Zhu (ORCID: https://orcid.org/0009-0007-4161-1640)
- Xinli Deng
- Yazhuo Hu
- Bo Yang (ORCID: https://orcid.org/0000-0002-8989-9387)
- Xi Yin (ORCID: https://orcid.org/0000-0002-7224-5272)
- Su‐Xia Li (ORCID: https://orcid.org/0000-0002-0781-0300)
- Shengshu Wang (ORCID: https://orcid.org/0000-0002-8801-1251)
- Geping Qu
- Linggen Gao (ORCID: https://orcid.org/0000-0002-2185-9936)
- Bo Zhou (ORCID: https://orcid.org/0000-0003-1063-2493)
- Ke Li (ORCID: https://orcid.org/0000-0003-4869-5393)
- Miao Liu (ORCID: https://orcid.org/0000-0002-7975-6702)
- Shuxia Wang
- Qi Zhang (ORCID: https://orcid.org/0000-0003-0564-9215)
- Fan Wang (ORCID: https://orcid.org/0000-0001-9806-5037)
- Lin Liu (ORCID: https://orcid.org/0000-0001-9690-1302)
- Lu Zhang (ORCID: https://orcid.org/0000-0002-4626-5990)
- Yang Yang (ORCID: https://orcid.org/0000-0002-4365-6179)
- Man Li (ORCID: https://orcid.org/0000-0002-6754-143X)
- Wenhui Liu (ORCID: https://orcid.org/0000-0001-7575-5561)
- Lei Li (ORCID: https://orcid.org/0000-0002-8828-5199)
- Qing Song (ORCID: https://orcid.org/0000-0001-7447-0388)
- Jianjun Jia (ORCID: https://orcid.org/0000-0002-0747-4132)
- Yajuan Wang
- Hui Shi (ORCID: https://orcid.org/0000-0003-1180-7443)
- Lining Xu (ORCID: https://orcid.org/0009-0000-5090-4591)
- Wenning Lu
- Jin Sun
- Tingyu Zhou
- Cong Ma (ORCID: https://orcid.org/0009-0006-6568-9226)
- Qiang Ma (ORCID: https://orcid.org/0000-0001-9086-4248)
- Li An (ORCID: https://orcid.org/0000-0002-8297-7776)
- Ru Zhang (ORCID: https://orcid.org/0000-0003-2710-0477)
- Xiangqun Fang (ORCID: https://orcid.org/0000-0002-9687-9683)
- Haili Huang (ORCID: https://orcid.org/0000-0001-9099-7999)
- Zhijian Zhang (ORCID: https://orcid.org/0009-0001-5441-532X)
- Yao He (ORCID: https://orcid.org/0000-0001-6205-7895)
- Bangguo Qin
- Jinling Ma
- Peng Song
- Nan Zhang (ORCID: https://orcid.org/0000-0001-6770-3534)
- Yongyi Bai
- Wei Zhang (ORCID: https://orcid.org/0000-0003-2971-240X)
Institutions
- Chinese PLA General Hospital (CN)
- PLA Academy of Military Science (CN)
Publication Details
- Journal
- Journal of Medical Virology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jmv.70207
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00