Comparative Analysis of Three Different Types of Gami-Saengmaeksan in Enhancing the Immune System

With infectious diseases and an aging population on the rise worldwide, there is a growing interest in boosting immunity to combat them. We aim to identify forest resources that can enhance immune function and scientifically prove their efficacy. We examined three different types of gami-saengmaeksan can increase the immune function in cyclophosphamide-induced immunosuppression mice. First, we injected cyclophosphamide (50 mg/kg) twice to induce immunosuppression. Then, three different types of gami-saengmaeksan (Prunus davidiana Carrière gami-saengmaeksan; PDS, Chaenomeles sinensis Koehne gami-saengmaeksan; CSS, Pyrus pyrifolia Nakai gami-saengmaeksan; PPS) 200 mg/kg/day were oral administered for 14 days. In order to confirm the immune-enhancing effect three different types of gami-saengmaeksan, we analyzed body weight chagne, the number of immune cells in blood, cytokines, and immunoglobulins levels in serum. Cyclophosphamide was decreased the mice body weight and the number of immune cells in blood. However, PDS and PPS have significantly increased the body weight, white blood cell, neutrophil, lymphocyte and monocyte count. Also, they were increased immune-related cytokines (IFN-γ, IL-2, IL-4, IL-6, IL-10, and TNF-α) and immunoglobulins (IgA, IgG, and IgM) levels in serum. But, CSS were slightly increased body weight, immune cells, cytokines, and immunoglobulins levels, non-significance was observed. The results suggest that the three types of gami-saengmaeksan can be used as ingredients in dietary supplements to immune enhancing.