Synthesis and Biological Activity of a Novel Derivatives of Schiff Base

Since their discovery, Schiff bases have been essential compounds that can be found in nature or synthesized in laboratories. We synthesized new schiff bases (1-3), namely as 4-{(E)-[4-(chloromethyl)phenyl]diazenyl}-2-{[(4-substituted phenyl)imino]-methyl}phenol. These derivatives are synthesized from the 5-{(E)-[4-(chloromethyl)phenyl]diazenyl}-2-hydroxybenzaldehyde and 4-substituted aniline, such as 4-methyl aniline, 4-chloro aniline,and4-methoxy aniline. Characterization of these compounds by FTIR and 1HNMRspectroscopy. The diffusion method is used to determine how these compounds interact with various bacteria, such as Bacillus subtilis, S. aureus and E. coli. The derivative 2 a good result to inhibition zone of bacteria growth.