Omentin-1 as Predictors for Cardiovascular Disease in Polycystic Ovarian Syndrome

Background & Objective: PCOS is a common disease affecting females of childbearing age. It is the most common cause of infertility, in addition to other diseases like cardiovascular diseases (CVD). The present study was conducted with aim to predict CVD as a complication in PCOS by identifying the omentin-1 and the lipid profile.Materials & Methods: The study consists of 58 patients with PCOS. The subjects were divided into two subgroups according to AIP: (1st group (G1) was PCOS patient with AIP<0.5) and 2nd group (G2) is PCOS patient with AIP ≥ 0.5), and 30 apparently control female. ELISA technique was used to evaluate the level of serum hormones, fasting insulin, and omintin-1. The spectrophotometric methods were used to measure levels of lipid profile, and FSG was performed in all groups.Results: There was a significant increase in mean levels of glucose, insulin, IR, LH, LH / FSH ratio Testosterone and lipid profile in PCOS groups compared to the control group, except omentin-1 and HDL-C showed significant decrease in the PCOS patients’ groups when compared to control group (P0.0001). G2 group showed significant decrease in omentin-1 levels than G1 group (49.24±1.44 ng/ml vs. 88.32±2.32 ng/ml). The association between omentin-1 levels and CVD remained significant after adjusting for major risk factors in a multivariate analysis. ROC curve based on omentin-1 levels to predict the existence of CVD in PCOS patients was 0.831.Conclusion: The decreasing of omentin-1 may be added to an expanded danger of CVD in PCOS patient who had (AIP ≥ 0.5), although referred to the risk factors, e.g. HOMA-IR, dyslipidemia.