Neuroprotective Potentials Of Extracts From Moringa Oleifera And Musa Sapientum Against Cadmium Chloride-Induced Neurotoxicity In Rats Cerebri

Cadmium (Cd)-exposure in humans causes nervous system dysfunctions. In rats, Cd-exposure resulted in increases of nitric oxide and lipid peroxidation levels in the hippocampus. This study evaluated the neuroprotective potential of active drug compounds extracted from Moringa oleifera leaves (MO11) and Musa sapientum suckers (MS06) in cadmium chloride (CdCl2)-induced neurotoxicity in rats. Adult male Wistar rats totalling 24 in number, were grouped randomly into six with four rats per group. Group 1 served as the control. An intraperitoneal single-dose of CdCl2 was administered to rats of Groups 2 to 4 and 6 on Day 1. MO11-dose, MO11+MS06-doses, and Doxorubicin-dose were respectively administered to rats of Groups 3, 4, and 6 for post-treatment of CdCl2-induced neurotoxicity. Rats of Group 5 were administered Olive Oil-dose (vehicle) for 17 days. Tissue concentrations of catalase, superoxide dismutase, cyclo-oxygenase-2 and cytochrome P450 in rats’ cerebri were determined using ELISA. Statistical analyses (p ≤ 0.05) of data were conducted using the Mann-Whitney U Test. Results showed increased catalase levels, similar superoxide dismutase levels, decreased cytochrome P450 levels and decreased cyclo-oxygenase-2 levels in rats of Groups 3, 4, and 6 in comparison with Group 2. The tested extracts impacted some levels of neuroprotection, neuroregeneration, antioxidant and anticancer capacities against neurotoxicity caused by CdCl2 exposure.