Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma
σlnCl is strongly associated with systemic eosinophilic inflammation in severe type-2 high asthma. An early σlnCl response following anti-IL5 biologics identifies patients more likely to experience improvements in symptoms and lung function when systemic eosinophils are depleted. σlnCl may provide a sensitive route for tracking inflammation involving the small airways.
Authors
- Dominic Sandhu (ORCID: https://orcid.org/0000-0002-9969-4449)
- Graham Richmond (ORCID: https://orcid.org/0000-0003-2999-5067)
- Nick P. Talbot (ORCID: https://orcid.org/0000-0002-9186-8950)
- Lorenzo S. Petralia (ORCID: https://orcid.org/0000-0002-9259-3231)
- Nicholas M. J. Smith (ORCID: https://orcid.org/0000-0003-3206-9793)
- Grant A. D. Ritchie (ORCID: https://orcid.org/0000-0003-1663-7770)
- Ian Pavord (ORCID: https://orcid.org/0000-0002-4288-5973)
- Haopeng Xu (ORCID: https://orcid.org/0000-0002-0245-0844)
- Peter A. Robbins (ORCID: https://orcid.org/0000-0002-4975-0609)
- Nayia Petousi (ORCID: https://orcid.org/0000-0002-5524-020X)
- Asma Alamoudi (ORCID: https://orcid.org/0000-0001-8716-9703)
Institutions
- Universität Innsbruck (AT)
- University of Oxford (GB)
- Oxford University Hospitals NHS Trust (GB)
- Prince Sultan Military College of Health Sciences
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/bmjresp-2024-002721
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- GlaxoSmithKline
- National Institute for Health and Care Research
- University of Oxford
- China Scholarship Council
- Chinese Academy of Medical Sciences
- Engineering and Physical Sciences Research Council
- NIHR Oxford Biomedical Research Centre