FORMULATIONS AND CHARACTERIZATIONS OF TELANG FLOWER EXTRACT (CLITORIA TERNATEA L.) GEL USING HYDROXY PROPYL METHYL CELLULOSE (HPMC) AS GELLING AGENT AND ITS ANTIOXIDANT ACTIVITY

Objective: Telang flowers (Clitoria ternatea L.) are plants that contain a natural source of antioxidants that can be formulated in gel preparation with a variation of concentration of gelling agent Hydroxy Propyl Methyl Cellulose (HPMC). The purpose of this research was to know the difference in the levels of HPMC as a gelling agent against the physical properties and antioxidant activity of preparation of telang flower extract gel. Methods: The extraction of telang flowers is done by a maceration method with a 96% ethanol solvent. The gel was formulated with HPMC concentration variations of 2%, 2.5% and 3% respectively. The physical properties of the gel that were determined were organoleptic, pH, stickiness, spreadability, viscosity, and homogeneity. Antioxidant activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl). Data was analyzed statistically using a one-way ANOVA test with a 95% confidence level. Results: The results of the research showed that the best formula was formula II with a concentration of HPMC of 2.5%. The gel of extract telang flower has characteristics with a typical scent of the telang flower, the blue-purple color, homogeneous, pH was 6.393±0.01, stickiness was 1.203±0.7 s, spreadability was 4.17±0.1 cm, and viscosity was 3000±100 cP. The antioxidant activity (IC50) the gel was 101.42 ppm belongs to the category of moderate antioxidants. Conclusion: Gel extract of telang flowers with concentration gelling agent HPMC concentration of 2.5% had the best physical properties.

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Publication Details

Journal
International Journal of Applied Pharmaceutics
Published
2024-11-18
DOI
https://doi.org/10.22159/ijap.2024.v16s6.se2030
Primary Topic
Biochemical and Structural Characterization
Type
article
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article

FORMULATIONS AND CHARACTERIZATIONS OF TELANG FLOWER EXTRACT (CLITORIA TERNATEA L.) GEL USING HYDROXY PROPYL METHYL CELLULOSE (HPMC) AS GELLING AGENT AND ITS ANTIOXIDANT ACTIVITY

Riza Maulana, Setyo Nurwaini, Teguh Imanto, ARUNIYAL ALIMATUS SADIAH
1 links
International Journal of Applied Pharmaceutics
Biochemical and Structural Characterization
article

FORMULATIONS AND CHARACTERIZATIONS OF TELANG FLOWER EXTRACT (CLITORIA TERNATEA L.) GEL USING HYDROXY PROPYL METHYL CELLULOSE (HPMC) AS GELLING AGENT AND ITS ANTIOXIDANT ACTIVITY

Riza Maulana, Setyo Nurwaini, Teguh Imanto, ARUNIYAL ALIMATUS SADIAH
article en

Abstract

Objective: Telang flowers (Clitoria ternatea L.) are plants that contain a natural source of antioxidants that can be formulated in gel preparation with a variation of concentration of gelling agent Hydroxy Propyl Methyl Cellulose (HPMC). The purpose of this research was to know the difference in the levels of HPMC as a gelling agent against the physical properties and antioxidant activity of preparation of telang flower extract gel. Methods: The extraction of telang flowers is done by a maceration method with a 96% ethanol solvent. The gel was formulated with HPMC concentration variations of 2%, 2.5% and 3% respectively. The physical properties of the gel that were determined were organoleptic, pH, stickiness, spreadability, viscosity, and homogeneity. Antioxidant activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl). Data was analyzed statistically using a one-way ANOVA test with a 95% confidence level. Results: The results of the research showed that the best formula was formula II with a concentration of HPMC of 2.5%. The gel of extract telang flower has characteristics with a typical scent of the telang flower, the blue-purple color, homogeneous, pH was 6.393±0.01, stickiness was 1.203±0.7 s, spreadability was 4.17±0.1 cm, and viscosity was 3000±100 cP. The antioxidant activity (IC50) the gel was 101.42 ppm belongs to the category of moderate antioxidants. Conclusion: Gel extract of telang flowers with concentration gelling agent HPMC concentration of 2.5% had the best physical properties.

International Journal of Applied Pharmaceutics
Openalex Percentile: Top 78%
Biochemical and Structural Characterization
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