The Protective Effect of Low-dose Nicotine on Ischemia Stroke by Maintaining the Integrity of the Blood–Brain Barrier
The study demonstrates that nicotine at low concentrations exerts neuro-protective effects by supporting the integrity of BBB and subsequent endothelial viability after ischemic stroke. This finding suggests that targeting the BBB, especially endothelial cells, with nicotine treatment is a promising therapeutic strategy for brain injury after ischemic stroke.
Authors
- Zhao Dong (ORCID: https://orcid.org/0000-0002-4581-2569)
- Yao Fu (ORCID: https://orcid.org/0000-0002-5855-4706)
- Wei Deng (ORCID: https://orcid.org/0000-0003-4883-4226)
- Qian Jiang (ORCID: https://orcid.org/0000-0003-3097-0721)
- Xinyang Yan (ORCID: https://orcid.org/0009-0004-0919-8698)
- Zheng Chen (ORCID: https://orcid.org/0000-0001-7129-6644)
- Xianfang Rong
- Yun Liang (ORCID: https://orcid.org/0000-0002-0364-6195)
- Zhichao Chen (ORCID: https://orcid.org/0000-0003-2311-4345)
- Hai Tao
- Qianqian Pang (ORCID: https://orcid.org/0000-0002-4028-5560)
- Miao Wang
Institutions
- Sun Yat-sen University (CN)
- Dongguan University of Technology (CN)
- Shenzhen Institute of Innovation Design (China) (CN)
- Sino Biological (China) (CN)
- Shenzhen Technology University (CN)
Publication Details
- Journal
- Nicotine & Tobacco Research
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1093/ntr/ntaf034
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00