The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
The TF combination KLF7/MEF2 partially mimics the conditioning lesion effect, inducing axonal sprouting into a dorsal column lesion and driving significant RAG expression, and also promotes functional improvement.
Authors
- Callan L. Attwell
- Joost Verhaagen (ORCID: https://orcid.org/0000-0002-8341-1096)
- Ronald E. van Kesteren (ORCID: https://orcid.org/0000-0002-9592-3777)
- Nitish D. Fagoe
- Bastiaan Bijleveld
- August Benjamin Smit (ORCID: https://orcid.org/0000-0002-2286-1587)
- Matthew R. J. Mason (ORCID: https://orcid.org/0000-0002-1743-5532)
- Ruben Eggers (ORCID: https://orcid.org/0000-0001-7017-0791)
- Lotte Razenberg
- I. Cortés Maldonado (ORCID: https://orcid.org/0000-0003-0631-7079)
- Ward M. Ellenbroek
- Natascha Siersema
- Dédé Lamme
Institutions
- Netherlands Institute for Neuroscience (NL)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Royal Academy of Art (NL)
- Amsterdam Neuroscience (NL)
- Imperial College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1186/s13024-025-00805-4
- Citations
- 6
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Spinal Research