Exploring New Delhi Metallo Beta Lactamases in Klebsiella pneumoniae and Escherichia coli: genotypic vs. phenotypic insights
This study demonstrates the value of the RESIST-5 O.K.N.V.I. lateral flow assay as a rapid and reliable diagnostic tool for detecting bla<sub>NDM</sub> in Escherichia coli, with strong agreement to PCR and WGS. While performance for Klebsiella pneumoniae was lower, the assay offers a practical alternative in resource-limited settings, aiding antimicrobial stewardship and improving diagnostic capacities in high-burden regions.
Authors
- Timothy D. McHugh (ORCID: https://orcid.org/0000-0003-4658-8594)
- Saba Riaz (ORCID: https://orcid.org/0000-0002-6630-5689)
- Zahra Sadouki (ORCID: https://orcid.org/0000-0003-3332-7811)
- Noor Ul Ain (ORCID: https://orcid.org/0000-0003-3097-2997)
- Linzy Elton (ORCID: https://orcid.org/0000-0003-4270-1553)
Institutions
- University of Lahore (PK)
- University of the Punjab (PK)
- University College London (GB)
Publication Details
- Journal
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1186/s12941-025-00775-x
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18
Funders
- Commonwealth Scholarship Commission
- China Scholarship Council