Two new compounds from the roots of <i>Paeonia lactiflora</i> Pall. and their anti-inflammatory effects
Two new compounds (<b>1</b>-<b>2</b>), together with six known ones (<b>3-8</b>), were isolated from the roots of <i>Paeonia lactiflora</i> Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds <b>1-8</b> were determined using LPS-induced RAW 264.7 cells. Compounds <b>2, 6,</b> and <b>8</b> showed the most potent inhibitory activities on NO production with <i>IC<sub>50</sub></i> values of 17.34 ± 1.5, 27.22 ± 1.3, and 14.79 ± 1.7 μM, respectively. Compounds <b>4</b> and <b>7</b> showed moderate inhibitory activities. Compounds <b>3</b> and <b>5</b> showed relatively weak inhibitory activities.
Authors
- Jia‐Tong Wu (ORCID: https://orcid.org/0000-0002-1090-9766)
- Zhichao Hao
- Bing‐You Yang (ORCID: https://orcid.org/0000-0002-2310-2750)
- Haixue Kuang (ORCID: https://orcid.org/0000-0003-0535-2761)
- Yan Liu (ORCID: https://orcid.org/0000-0002-7682-3498)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-4339-1502)
- Siyi Wang (ORCID: https://orcid.org/0000-0002-3754-2861)
- Yiqiang Zhang (ORCID: https://orcid.org/0000-0003-0691-6645)
- Bo Fu (ORCID: https://orcid.org/0009-0001-3169-4119)
- Qingshan Chen (ORCID: https://orcid.org/0009-0004-1655-2210)
- Jinling Zhang (ORCID: https://orcid.org/0000-0001-8186-5919)
- Wei Guan (ORCID: https://orcid.org/0000-0002-7967-3456)
- Juan Pan
Institutions
- Northeast Agricultural University (CN)
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1080/14786419.2025.2462114
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.38