Transvitreal Retinochoroidal Biopsies of Primary Uveal Melanoma Reveal an Association of Low HLA Class I and High NK Cell Abundance in Low-Risk Disease
TVRC biopsies are a suitable and valuable source of PUM tissue for research purposes. An abundance of CD8 T cells was found in high-risk PUM tumors. Further, medium- and low-risk PUM tumors are characterized by decreased HLA class I expression with a concomitant increase in NK cell infiltration as compared to high-risk PUM tumors, correlating with decreased risk of disease recurrence.
Authors
- Pedro C. Lara (ORCID: https://orcid.org/0000-0003-1709-6232)
- Kalijn F. Bol (ORCID: https://orcid.org/0000-0003-4165-2040)
- Mark A.J. Gorris (ORCID: https://orcid.org/0000-0003-3621-226X)
- Marco Donia (ORCID: https://orcid.org/0000-0003-4966-9752)
- Michael D. Crowther (ORCID: https://orcid.org/0000-0003-4765-2818)
- Mette Bagger (ORCID: https://orcid.org/0000-0001-6381-8465)
- Inge Marie Svane (ORCID: https://orcid.org/0000-0002-9451-6037)
- Carsten Faber (ORCID: https://orcid.org/0000-0002-2517-7270)
- Johannes C. Textor (ORCID: https://orcid.org/0000-0002-0459-9458)
- Arianna Draghi (ORCID: https://orcid.org/0000-0002-5894-6750)
- Jens Folke Kiilgaard (ORCID: https://orcid.org/0000-0003-1054-1460)
- Mark W. D. Sweep (ORCID: https://orcid.org/0000-0002-3080-8903)
Institutions
- University of Copenhagen (DK)
- Radboud University Nijmegen (NL)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1167/iovs.66.2.24
- Citations
- 1
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71