Validation of childhood lupus specific targets: ensuring accurate assessment of disease control in younger, lighter paediatric patients
This study validates novel paediatric-specific targets, demonstrating that achieving cLLDAS, cCR and cCR-0 reduces risks of new damage and severe flare, which is comparable to aSLE targets. Using cSLE-specific targets prevents misclassification of disease activity in paediatric patients, enabling more accurate disease control assessments in younger, lighter patients.
Authors
- Annie Ratcliffe
- Daniel Hawley
- Athimalaipet V Ramanan
- Christian M. Hedrich (ORCID: https://orcid.org/0000-0002-1295-6179)
- Kukatharmini Tharmaratnam (ORCID: https://orcid.org/0000-0002-8255-9822)
- Zoe McLaren
- Heather Rostron (ORCID: https://orcid.org/0000-0001-8324-3451)
- Michael W. Beresford (ORCID: https://orcid.org/0000-0002-5400-9911)
- Eve Smith (ORCID: https://orcid.org/0000-0002-8371-7597)
- Ethan S Sen (ORCID: https://orcid.org/0000-0003-0135-6546)
- Kathryn Bailey (ORCID: https://orcid.org/0000-0003-4525-8673)
- Chandni Sarker
- Elena Moraitis
- Mary Brennan (ORCID: https://orcid.org/0000-0002-1775-9959)
- Philip Riley (ORCID: https://orcid.org/0000-0003-3902-6112)
- Coziana Ciurtin (ORCID: https://orcid.org/0000-0002-8911-4113)
- Kate Armon (ORCID: https://orcid.org/0000-0003-2835-4903)
- Alice Leahy
- Eslam Al‐Abadi (ORCID: https://orcid.org/0000-0002-1999-6341)
- Ellen Mosley
- Satyapal Rangaraj
- Andrea Jorgensen (ORCID: https://orcid.org/0000-0002-6977-9337)
- Janet Gardner‐Medwin
- Marek Böhm
- Alison Kinder
- Gulshan Malik
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Liverpool (GB)
- University of Cambridge (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Great Ormond Street Hospital (GB)
- Royal Hospital for Children (GB)
- Bradford Royal Infirmary (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Musgrove Park Hospital (GB)
- Southampton General Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Royal Liverpool and Broadgreen University Hospital NHS Trust (GB)
- University of Bristol (GB)
- Alder Hey Children's NHS Foundation Trust (GB)
- Bridge University (SS)
- Birmingham Children's Hospital (GB)
- Royal Aberdeen Children's Hospital (GB)
- Royal Hospital for Sick Children (GB)
- British Society for Rheumatology (GB)
- Great North Children's Hospital (GB)
- Oxford University Hospitals NHS Trust (GB)
- Royal Manchester Children's Hospital (GB)
- Sheffield Children's Hospital (GB)
- University College London (GB)
- University of Glasgow (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1093/rheumatology/keaf057
- Citations
- 4
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Alder Hey Children's NHS Foundation Trust
- Children's National Hospital
- National Institute for Health and Care Research
- Versus Arthritis
- LUPUS UK