Extracellular Matrix Stiffness Modulates Myopia Scleral Remodeling Through Integrin/F-Actin/YAP Axis
Our results suggest that the integrin α1β1-F-actin-YAP-COL1A1 axis constitutes a vital regulatory mechanism intrinsically associated with the pathogenesis of myopia.
Authors
- Yuying Liu (ORCID: https://orcid.org/0000-0002-2781-7411)
- Bilian Ke (ORCID: https://orcid.org/0000-0002-4290-4089)
- Chengcheng Zhu (ORCID: https://orcid.org/0000-0001-6898-549X)
- Yue Wu (ORCID: https://orcid.org/0000-0002-9073-5988)
- Xin Liu (ORCID: https://orcid.org/0000-0003-0405-1406)
- Ying Yuan (ORCID: https://orcid.org/0000-0001-8501-197X)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1167/iovs.66.2.22
- Citations
- 15
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 20.40