Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling
Cardiomyocyte-specific MC1R deficiency attenuates physiological and pathological cardiac hypertrophy in mice, while pharmacological activation of MC1R promotes cardiomyocyte hypertrophy.
Authors
- Eriika Savontaus (ORCID: https://orcid.org/0000-0003-3421-0367)
- Virpi Talman (ORCID: https://orcid.org/0000-0002-2702-6505)
- Saku Ruohonen (ORCID: https://orcid.org/0000-0003-2503-148X)
- Anni Suominen
- Petteri Rinne (ORCID: https://orcid.org/0000-0001-6916-8627)
- Minying Cai (ORCID: https://orcid.org/0000-0001-9504-2091)
- Risto Kerkelä (ORCID: https://orcid.org/0000-0001-7194-9326)
- Zoltán Szabó (ORCID: https://orcid.org/0000-0003-0778-1113)
- Lotta Pohjolainen (ORCID: https://orcid.org/0000-0001-8852-6709)
- Aino Suni (ORCID: https://orcid.org/0009-0003-4665-7374)
Institutions
- University of Helsinki (FI)
- University of Arizona (US)
- University of Turku (FI)
- Oulu University Hospital (FI)
- Turku University Hospital (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1161/jaha.124.037961
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Foundation for Cardiovascular Research
- Suomen Kulttuurirahasto
- Turun Yliopisto
- Sydäntutkimussäätiö
- Sigrid Juséliuksen Säätiö