Descriptive analysis and outcomes of PitNETs treated surgically during pregnancy and postpartum
Among the 10 PitNETs, 4 were corticotropic, 2 gonadotropic, 2 lactotropic, and 2 somatotropic. The primary surgical indication (tumour syndrome with or without failure of medical treatment) was similar between the two groups: 7/10 vs 19/30 (P = 1.00). There was no statistically significant difference in volume (P = .072) or radiological invasion markers (optic chiasm compression, P = .059, and cavernous sinus invasion, P = .274). However, PitNETs in pregnant women showed higher mitotic activity (P = .038) and were more frequently classified as grade 2b (Trouillas clinicopathological classification; P = .049). The need for second-line treatment was also more frequent (P = .005). PitNETs requiring surgical treatment during pregnancy are characterized by increased proliferative activity and progression after surgery. Despite this, the long-term prognosis remains favourable. These results need confirmation in a larger study.
Authors
- Philippe Caron (ORCID: https://orcid.org/0000-0001-5391-7582)
- Théophraste Henry (ORCID: https://orcid.org/0000-0003-0672-415X)
- Yves Reznik (ORCID: https://orcid.org/0000-0002-6267-8058)
- Bertrand Baussart (ORCID: https://orcid.org/0000-0003-0735-8278)
- Claude Ghorra (ORCID: https://orcid.org/0000-0002-1262-6903)
- Mirella Hage (ORCID: https://orcid.org/0000-0002-7458-7102)
- Chiara Villa (ORCID: https://orcid.org/0000-0001-6245-4487)
- Mathilde Brière
- A. Rod
- S. Gaillard (ORCID: https://orcid.org/0000-0001-6555-8919)
- Marie‐Laure Raffin‐Sanson (ORCID: https://orcid.org/0000-0001-5872-4544)
- Cindy Odot
- Lionel Groussin
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Royal University Hospital (CA)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Maternité Port Royal (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Larrey (FR)
- Hôpital Ambroise-Paré (FR)
- Institut Cochin (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1093/ejendo/lvaf018
- Citations
- 1
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Assistance Publique - Hôpitaux de Paris