Muscone enhances synaptic function in vascular dementia through activating BDNF-TrkB-NP2 signaling pathway
The activation of the BDNF-TrkB-NP2 pathway and synaptic function enhancement by Muscone contribute to its protective effect against VD injury. Therefore, our study uncovers a novel mechanism underlying the anti-VD properties of Muscone.
Authors
- Xian Zhou (ORCID: https://orcid.org/0000-0001-8766-8158)
- Kai Zhu (ORCID: https://orcid.org/0000-0002-9437-5254)
- Dennis Chang (ORCID: https://orcid.org/0000-0002-6584-738X)
- Yuang Chen (ORCID: https://orcid.org/0000-0001-8733-3948)
- Ping Huang (ORCID: https://orcid.org/0009-0003-2742-7207)
- Hao Sun (ORCID: https://orcid.org/0000-0002-8723-9932)
- Yuqin Peng
- Jiacheng Li (ORCID: https://orcid.org/0009-0007-1308-2550)
- Ning Wang (ORCID: https://orcid.org/0000-0003-1241-7164)
- Chaowen Ge
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
- Westmead Institute (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1016/j.intimp.2025.114232
- Citations
- 6
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.05