ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance
We identified ACC1 as a metabolic checkpoint in Treg biology. Our data demonstrate that ACC1 inhibition promotes Treg differentiation and long-term stability in vitro and in vivo. Thus, ACC1 serves as a dual metabolic and epigenetic hub, regulating immune tolerance and inflammation by balancing de novo lipid synthesis and protein acetylation.
Authors
- Luciana Berod (ORCID: https://orcid.org/0000-0002-9677-3483)
- Philipp Stüve
- Matthias Lochner (ORCID: https://orcid.org/0000-0002-7979-5613)
- Ingo Schmitz (ORCID: https://orcid.org/0000-0002-5360-0419)
- Wolf‐Rainer Abraham (ORCID: https://orcid.org/0000-0002-2850-2649)
- Fernando N. Ferreyra
- Michael Rehli (ORCID: https://orcid.org/0000-0003-3992-932X)
- Gloria J. Godoy
- Benoı̂t L. Salomon (ORCID: https://orcid.org/0000-0001-9673-5578)
- Tushar H. More
- Tim Sparwasser (ORCID: https://orcid.org/0000-0001-5645-902X)
- Fatima Boukhallouk (ORCID: https://orcid.org/0000-0002-2471-7108)
- Karsten Hiller (ORCID: https://orcid.org/0000-0001-9322-5820)
- Tatiana Akimova (ORCID: https://orcid.org/0000-0003-2767-8762)
- Anne-Marie Matthies
- Ulf H. Beier (ORCID: https://orcid.org/0000-0002-3672-572X)
- Yu-San Kao (ORCID: https://orcid.org/0000-0003-2571-853X)
- Volkhard Kaever
- Florencia Hellriegel
Institutions
- Centre National de la Recherche Scientifique (FR)
- Children's Hospital of Philadelphia (US)
- Inserm (FR)
- Universidad Nacional de Córdoba (AR)
- Johannes Gutenberg University Mainz (DE)
- University Hospital Regensburg (DE)
- Sorbonne Université (FR)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Research Centre in Biological Chemistry of Córdoba (AR)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
- Center for Experimental and Clinical Infection Research (DE)
- Hannover Re (Germany) (DE)
- University of Pennsylvania (US)
- Technische Universität Braunschweig (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1016/j.molmet.2025.102111
- Citations
- 15
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 12.09
Funders
- Boehringer Ingelheim Fonds
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Medizinischen Hochschule Hannover
- Boehringer Ingelheim Stiftung
- Leibniz-Gemeinschaft