Penile endothelial dysfunction, impaired redox metabolism and blunted mitochondrial bioenergetics in diet-induced obesity: Compensatory role of H2O2
Mitochondrial dysfunction with impaired bioenergetics and reduced mitoK<sub>ATP</sub> channel-mediated relaxation underlie endothelial and vascular dysfunction of erectile tissue in obesity, despite a compensatory mechanism that enhances Nox4-derived endothelial vasodilator mtROS. Therapeutic strategies aimed to stabilize mitochondria could restore redox balance and improve mitochondrial bioenergetics thus preventing oxidative stress and vascular dysfunction underlying metabolic disease associated ED.
Authors
- Ulf Simonsen (ORCID: https://orcid.org/0000-0002-2169-7666)
- Cristina Contreras (ORCID: https://orcid.org/0000-0002-7015-7922)
- Dolores Prieto (ORCID: https://orcid.org/0000-0001-7049-5991)
- J. Sáenz Medina (ORCID: https://orcid.org/0000-0002-8568-854X)
- Luis Rivera (ORCID: https://orcid.org/0000-0002-0187-707X)
- Pilar Martínez Narváez-Cabeza de Vaca (ORCID: https://orcid.org/0000-0002-2224-7632)
- Ana Sánchez (ORCID: https://orcid.org/0000-0003-3283-8812)
- Alfonso Gómez del Val
- Óscar Freire-Agulleiro (ORCID: https://orcid.org/0000-0001-9843-2650)
- Miguel López (ORCID: https://orcid.org/0009-0006-5314-2231)
- Mercedes Muñoz (ORCID: https://orcid.org/0000-0002-1679-9588)
- Lucía Olmos (ORCID: https://orcid.org/0009-0008-5043-5084)
- Simon Gabriel Comerma-Steffensen
Institutions
- Universidad Complutense de Madrid (ES)
- Aarhus University (DK)
- Instituto Cajal (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.02.004
- Citations
- 7
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.15
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Ministerio de Ciencia e Innovación