Neuroprotective Activity of Amaranthus tricolor Leaves Extract for Haloperidol Induce Catalepsy by Behavior Method

This research study evaluates the effect of the neuroprotective activity of the dried leaves extract of Amaranthus tricolor (LEAT) on haloperidol causing catalepsy in laboratory rats. The catalepsy is caused by intraperitoneal administration of haloperidol (1mg/kg). The composition of the LEAT extracts at low and high dosages, and the standard drugs being tested were given orally (p.o.) 30 minutes before treatment with haloperidol and catalepsy was measured using behavioral test models. The efficacy and inhibition of catalepsy were calculated by the one-way ANOVA method. According to the findings of the phytochemical screening, the LAT contains flavonoids, saponins, alkaloids, tannins, sterols, amino acids, carbohydrates proteins, &fats. An acute oral toxicity study investigation on the LAT, but not through a report of its toxicity was available. The outcomes demonstrate that the LEAT low dose considerably (p<0.001) decline the catalepsies score after giving haloperidol for 30, 60, 90, 120, 150, and 180 minutes. The catalepsies score was significantly (p<0.001) declined by both standard drug (levodopa 5mg/kg) and LAT high dose in comparison to the disease control group. The levodopa 5mg/kg with LEAT 400mg/kg also significantly (p<0.001) declines the catalepsy score. The research suggested that levodopa-infused LEAT significantly enhanced efficacy in comparison to the disease control group. As a result, the study concludes that A. tricolor combined with levodopa can potentially manage neurodegenerative disease because it affects almost all of the medals.