Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study
This study provides a detailed description of spleen morphology and the factors influencing its size in a rural central African population. It demonstrates a strong association between L. loa MFD and reduced SV, suggesting that loiasis may lead to AH, and potentially to functional hyposplenia, with consequences such as increased susceptibility to bacterial infections. Malaria was associated with splenomegaly, with a figure of HMS consistent with estimates from other African countries.
Authors
- Jérémy T. Campillo (ORCID: https://orcid.org/0000-0002-4400-5204)
- Jean Claude Djontu (ORCID: https://orcid.org/0000-0002-5035-4515)
- François Missamou (ORCID: https://orcid.org/0000-0002-6388-0266)
- P. Souteyrand
- Ludovic G. Rancé
- Marlhand C. Hemilembolo
- Francine Ntoumi (ORCID: https://orcid.org/0000-0003-4748-050X)
- Charlotte Boullé (ORCID: https://orcid.org/0000-0002-3800-6315)
- Cédric B. Chesnais (ORCID: https://orcid.org/0000-0002-8779-977X)
- Valentin Dupasquier (ORCID: https://orcid.org/0009-0009-1926-2231)
- Michel Boussinesq (ORCID: https://orcid.org/0000-0001-6312-0681)
- Elodie Lebredonchel (ORCID: https://orcid.org/0000-0001-5119-6005)
- Sébastien D. S. Pion (ORCID: https://orcid.org/0000-0002-9468-7020)
Institutions
- Institut de Recherche pour le Développement (BJ)
- Inserm (FR)
- Université de Montpellier (FR)
- Agropolis International (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Fondation Congolaise Pour La Recherche Médicale (CG)
- Centre Hospitalier et Universitaire de Brazzaville (CG)
- Institute for Sustainable Development (ET)
- Institut de Recherche pour le Développement (FR)
- University of Tübingen (DE)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1186/s40249-025-01277-w
- Citations
- 2
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Institut de Recherche pour le Développement
- European Commission
- Institut National de la Santé et de la Recherche Médicale
- Fondation Bettencourt Schueller
- HORIZON EUROPE European Research Council