Long-term cardiac MRI follow up of MANTICORE (Multidisciplinary Approach to Novel Therapies in Cardio-Oncology REsearch)
The findings suggest that in a selected population receiving trastuzumab-based chemotherapy, extended cardiac imaging surveillance beyond one-year post-treatment may be unnecessary. We posit that the presence of HER2 overexpressing breast cancer influenced hypertrophic changes to cardiac geometry observed at baseline and one year, which resolved after completing HER2-blocking treatment. The study also highlights the need for further research to understand the significance of changes in cardiac geometry during and after breast cancer treatment.
Authors
- Edith Pituskin (ORCID: https://orcid.org/0000-0003-0660-7834)
- Richard B. Thompson (ORCID: https://orcid.org/0000-0003-3319-4377)
- John Robert Mackey (ORCID: https://orcid.org/0000-0002-3489-2161)
- Mark J. Haykowsky (ORCID: https://orcid.org/0000-0002-7217-2747)
- D. Ian Paterson (ORCID: https://orcid.org/0000-0003-4529-3102)
- Dina Labib (ORCID: https://orcid.org/0000-0001-7108-8554)
- Emer Sonnex (ORCID: https://orcid.org/0000-0003-4774-611X)
Institutions
- BC Cancer Agency (CA)
- Cairo University (EG)
- University of Ottawa (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- Libin Cardiovascular Institute of Alberta (CA)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1186/s40959-025-00313-w
- Citations
- 2
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Heart and Stroke Foundation of Canada
- University of Ottawa
- Government of Canada
- University of Alberta