Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data
Alteplase has consistent efficacy regardless of prior APT in patients with unknown onset stroke. In addition, prior APT does not significantly increase the risk of sICH or mortality.
Authors
- Yuma Shiomi
- Ona Wu (ORCID: https://orcid.org/0000-0002-5509-9461)
- Mayumi Fukuda‐Doi (ORCID: https://orcid.org/0000-0003-0922-4417)
- Götz Thomalla (ORCID: https://orcid.org/0000-0002-4785-1449)
- Sohei Yoshimura (ORCID: https://orcid.org/0000-0002-4751-3538)
- Ḱazunori Toyoda (ORCID: https://orcid.org/0000-0002-8346-9845)
- Naruhiko Kamogawa (ORCID: https://orcid.org/0000-0002-5177-8248)
- Manabu Inoue (ORCID: https://orcid.org/0000-0001-5228-6643)
- Geoffrey Alan Donnan (ORCID: https://orcid.org/0000-0001-6324-3403)
- Masatoshi Koga (ORCID: https://orcid.org/0000-0002-6758-4026)
- Märit Jensen (ORCID: https://orcid.org/0000-0001-7793-0941)
- Jin Nakahara (ORCID: https://orcid.org/0000-0002-5858-0998)
- Stephen M. Davis (ORCID: https://orcid.org/0000-0003-0962-2300)
- Peter A. Ringleb (ORCID: https://orcid.org/0000-0002-5473-8671)
- Henry Ma (ORCID: https://orcid.org/0000-0002-0510-8059)
- Christian Gerloff (ORCID: https://orcid.org/0000-0002-6484-8882)
- Lee H. Schwamm (ORCID: https://orcid.org/0000-0003-0592-9145)
- Kaori Miwa (ORCID: https://orcid.org/0000-0002-7948-3636)
Institutions
- The Royal Melbourne Hospital (AU)
- Universität Hamburg (DE)
- The University of Melbourne (AU)
- Keio University (JP)
- Heidelberg University (DE)
- Yale University (US)
- Massachusetts General Hospital (US)
- University Medical Center Hamburg-Eppendorf (DE)
- National Cerebral and Cardiovascular Center (JP)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Klinik und Poliklinik für Neurologie (DE)
- Monash University (AU)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1177/17474930251322034
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35