Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk
Higher CHOL and LDLC levels were associated with increased ALS risk, suggesting a potential causal link, and supporting the liver‒brain axis hypothesis in ND. Current genetic evidence does not support a significant role for lipid metabolism in PD and MS etiology, suggesting the relationship between lipid metabolism and other NDs may be more complex and warrants further investigation.
Authors
- Guangyong Sun (ORCID: https://orcid.org/0000-0002-7179-6435)
- Zixiao Yin (ORCID: https://orcid.org/0000-0001-7088-8031)
- Dong Zhang (ORCID: https://orcid.org/0000-0001-7323-7699)
- Zeyu Wang (ORCID: https://orcid.org/0000-0003-0087-8123)
- Jianguo Zhang (ORCID: https://orcid.org/0000-0001-9314-0800)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing Institute of Neurosurgery (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-02-08
- DOI
- https://doi.org/10.1186/s12944-025-02455-3
- Citations
- 10
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 13.89