Selection of rectal cancer patients for organ preservation after neoadjuvant therapy: value of T2W-MRI signal intensity

BackgroundOrgan preservation strategies have been widely implemented for rectal cancer (RC) patients with a good response after neoadjuvant chemoradiation (nCRT). However, to accurately select eligible patients remains one of the key diagnostic challenges.PurposeTo identify eligible candidates for organ preservation after nCRT in RC, by identifying luminal response and lymph node metastases, based on T2W-MRI signal intensities.Material and MethodsA total of 171 RC patients underwent MRI before and after nCRT. The primary tumor (pre-nCRT-MRI) and tumor remnant (post-nCRT-MRI) were manually delineated. Ten signal intensity features were extracted and delta features were calculated by subtraction. Histopathological evaluation classified patients as lymph node negative (ypN0) or positive (ypN+), and as good responders (GR) or partial/poor responders (PR). Five models were constructed based on the timing of imaging.Results42/170 (25%) patients had ypN+, and 72/152 (47%) patients were considered GR. Univariate analysis showed 13/40 signal intensity features were significantly different between luminal response groups and 4/40 between nodal response groups. In multivariate analysis, the <i>Baseline + Restaging-model</i> yielded the best results for both luminal and nodal response with AUCs in the test set of 0.81 (95% CI=0.67-0.95) and 0.74 (95% CI=0.59-0.90), respectively. To identify PR, the <i>Delta-model</i> yielded an AUC of 0.72 (95% CI=0.56-0.89) and the <i>Delta + Restaging-model</i> an AUC of 0.81 (95% CI=0.67-0.95), both were not able to differentiate nodal response. The models including solely baseline or restaging features were not predictive.ConclusionT2W-MRI signal intensities of the primary rectal tumor are related to the luminal and nodal response after nCRT and hold promise to identify patients eligible for organ preservation.