Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making
Persistent eGFR<sub>cre</sub> decrease to < 90 ml/min/1.73 m<sup>2</sup> after switch to DTG was common in this Thai population. eGFR<sub>cystC</sub> was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART modifications. Trial registration Clinical Trials Registry Number: ClininicalTrials.gov NCT00796146.
Authors
- Charles Austin (ORCID: https://orcid.org/0000-0002-5253-0623)
- Orlanda Goh (ORCID: https://orcid.org/0000-0001-8423-2703)
- Phillip Chan (ORCID: https://orcid.org/0000-0002-4071-4409)
- Sandhya Vasan (ORCID: https://orcid.org/0000-0002-6378-6288)
- Nittaya Phanuphak (ORCID: https://orcid.org/0000-0002-0036-3165)
- Suteeraporn Pinyakorn (ORCID: https://orcid.org/0000-0003-3880-4381)
- Carlo Sacdalan (ORCID: https://orcid.org/0000-0002-5839-4837)
- Jintanat Ananworanich (ORCID: https://orcid.org/0000-0003-1369-3224)
- Nitiya Chomchey (ORCID: https://orcid.org/0000-0002-0539-4542)
- Tassanee Luekasemsuk
- Eugène Kroon (ORCID: https://orcid.org/0000-0002-8235-7155)
- Merlin L. Robb (ORCID: https://orcid.org/0000-0003-3949-9649)
- Denise C. Hsu (ORCID: https://orcid.org/0000-0001-7530-0508)
- Donn Colby (ORCID: https://orcid.org/0000-0003-3931-5926)
- Jintana Intasan
- Aswathy Varma
- Krittaporn Pornpaisakul
Institutions
- Henry M. Jackson Foundation (US)
- Chulalongkorn University (TH)
- University of Milan (IT)
- Washington University in St. Louis (US)
- Yale University (US)
- HIV Netherlands Australia Thailand Research Collaboration (TH)
- Amsterdam Institute for Global Health and Development (NL)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- AIDS Research and Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12981-025-00712-0
- Citations
- 1
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- U.S. Department of Defense
- Henry M. Jackson Foundation
- Gilead Sciences
- ViiV Healthcare
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases