Single-cell RNA sequencing of circulating immune cells supports inhibition of TNFAIP3 and NFKBIA translation as psoriatic arthritis biomarkers
These results suggest that translation of <i>TNFAIP3</i> and <i>NFKBIA</i> may be inhibited in PsA CD8<sup>+</sup> T cells. This study provides insight into the cellular heterogeneity of PsA, showing that non-cell type specific expression of genes associated with the disease can be dysregulated through different mechanisms in distinct cell types.
Authors
- Alícia Garrido (ORCID: https://orcid.org/0000-0003-0652-6348)
- Omar Fernando Cruz-Correa (ORCID: https://orcid.org/0000-0003-3364-6353)
- Joan Wither
- Darshini Ganatra (ORCID: https://orcid.org/0000-0002-3676-9124)
- Igor Jurišica (ORCID: https://orcid.org/0000-0002-2507-946X)
- Rohan Machhar
- Sarah Q. Crome (ORCID: https://orcid.org/0000-0001-5117-7453)
- Dafna D. Gladman
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Slovak Academy of Sciences (SK)
- Discovery Centre (CA)
- Krembil Foundation (CA)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- Krembil Research Institute
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1483393
- Citations
- 5
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Krembil Foundation
- Canadian Institutes of Health Research