Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways
LAF showed anti-TNBC effect both <i>in vitro</i> and <i>in vivo.</i> Reversal of EMT by inhibiting GSK-3β/YAP/β-catenin signaling and PI3K/AKT/mTOR signaling contributes to the effect.
Authors
- Zhuohui Luo (ORCID: https://orcid.org/0000-0001-5288-2066)
- Yuanhao Hu
- Xiaoling Shen (ORCID: https://orcid.org/0000-0003-1688-7913)
- Guiyun Wu
- Qiqi Meng
- Xiaofeng He (ORCID: https://orcid.org/0000-0002-6911-348X)
- Jiawen Huang (ORCID: https://orcid.org/0000-0002-5340-2770)
- Zhiping Li
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Hainan University (CN)
- Hainan Agricultural School (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.3389/fphar.2025.1496511
- Citations
- 3
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 3.45